Having a satisfying and healthy sex life is crucial for maintaining a good quality of life. When certain factors impede our ability to fully enjoy sex, it’s understandable that many people become frustrated and anxious. Fortunately, medications like Vyleesi have been developed to alleviate these issues and enhance sexual experience. However, one of the key concerns about this medication is how long does Vyleesi last? Knowing the answer to this question is essential for planning a healthy sex life.
Vyleesi is a non-hormonal medication that is used to boost sexual desire in women. It is a relatively new medication in the market, and many women are curious about how long it lasts. The medication is administered via an injection at least 45 minutes before sexual activity. According to the manufacturers, the medication can last up to 24 hours, giving women enough time to enjoy quality sexual experiences with their partners. However, the duration may vary from one woman to another, depending on factors such as age, weight, and metabolism.
Knowing how long Vyleesi lasts is important for women who are struggling with sexual dysfunction. The medication can provide much-needed relief and restore confidence in sexual performance. However, it’s important to consult a medical expert before using such medications. Vyleesi may come with certain side effects, and it’s essential to understand any risks involved. But ultimately, the positive effects of the medication can provide a much-needed boost to women who are struggling with intimacy issues. So, go ahead and talk to your healthcare provider to see if Vyleesi may be worth a shot in enhancing your sexual wellness.
What is Vyleesi?
Vyleesi (bremelanotide) is a prescription medication that was approved by the FDA in 2019 to treat hypoactive sexual desire disorder (HSDD) in premenopausal women. HSDD is a condition in which women experience a persistent lack of interest or desire for sexual activity, causing significant distress in their personal relationships and quality of life.
Vyleesi works by activating melanocortin receptors in the brain, which have been shown to increase sexual desire and arousal. Unlike other medications used to treat HSDD, such as Addyi, Vyleesi is not taken daily but rather on an as-needed basis before sexual activity. Vyleesi is administered as a self-injection under the skin of the abdomen or thigh, approximately 45 minutes before sexual activity.
It is important to note that Vyleesi is not a magic pill. It does not work for everyone and may not necessarily increase the frequency of sexual activity. However, it can help women who struggle with HSDD by increasing their overall sexual desire and improving their sexual experiences.
How does Vyleesi work?
Vyleesi is a medication commonly used to treat hypoactive sexual desire disorder (HSDD) in women. HSDD is a condition characterized by a lack of sexual desire and it affects a significant number of women worldwide. Vyleesi works by mimicking the melanocortin peptide, which is responsible for regulating sexual activity, appetite, and other physiological processes in the body.
When Vyleesi is injected, it stimulates a natural response from the body by activating the melanocortin 4 receptor and mimicking the effects of natural MSH peptides. This leads to an increase in sexual desire in women and helps to treat the symptoms of HSDD. It is important to note that this medication does not increase sexual performance or help with arousal, as it only works to increase sexual desire.
How long does Vyleesi last?
- The effects of Vyleesi can last for up to 24 to 48 hours after administration.
- Some women may experience a delayed onset of effectiveness, which may occur up to 3 hours after administration.
- The effectiveness of Vyleesi may vary from person to person.
Potential side effects of Vyleesi
Like any medication, Vyleesi may cause side effects in some people. Common side effects of Vyleesi include:
- Nausea and vomiting
- Flushing
- Headaches
- Injection site reactions
If you experience any severe side effects or an allergic reaction, seek immediate medical attention.
How to use Vyleesi
Vyleesi is administered as an injection into the thigh or abdomen area, 45 minutes before sexual activity. Unlike other medications used to treat HSDD, Vyleesi should not be used every day, as the effects can last up to 24 to 48 hours. It is recommended to use no more than 8 doses per month, at least 24 hours apart.
| Dosage | Administration method |
|---|---|
| 1.75 mg | Subcutaneous injection into the abdomen or thigh |
| 110 mcg | Nasal spray (not currently available in the United States) |
Speak with your healthcare provider to determine if Vyleesi is the right medication for you, and to discuss any potential risks or side effects.
FDA Approval of Vyleesi
After years of research and clinical trials, the U.S. Food and Drug Administration (FDA) approved Vyleesi (bremelanotide) injection on June 21, 2019, to treat acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. This marked a significant step in the treatment of female sexual dysfunction.
- Acquired, generalized HSDD is characterized by a persistent or recurrent deficiency or absence of sexual fantasy and desire for sexual activity, causing marked distress or interpersonal difficulty and not due to a co-existing medical or psychiatric condition, relationship problems, or medication side effects.
- Vyleesi is a melanocortin receptor agonist that works by activating the central nervous system to increase sexual desire and arousal. It should be administered subcutaneously (under the skin) at least 45 minutes before anticipated sexual activity and no more than once within 24 hours.
- The approval of Vyleesi by the FDA was based on two randomized, double-blind, placebo-controlled clinical trials that involved more than 1,200 premenopausal women with acquired, generalized HSDD. The trials demonstrated that women who received Vyleesi had a significant increase in their sexual desire score compared to those who received a placebo.
The approval of Vyleesi provides a new option for women who struggle with acquired, generalized HSDD. It is important to note that Vyleesi may not work for every woman and has potential side effects, including nausea, flushing, injection site reactions, headache, and vomiting. Women should talk to their healthcare provider to see if Vyleesi is a good option for them.
| Criteria | Placebo Group (n = 375) | Vyleesi Group (n = 375) |
|---|---|---|
| Mean baseline Female Sexual Function Index (FSFI) Score | 2.95 | 2.94 |
| Mean change from baseline in FSFI desire domain score at week 24 | -0.85 | 0.56 |
| Percent with clinically meaningful improvement in FSFI desire domain score at week 24 | 17% | 35% |
| Mean change from baseline in Female Sexual Distress Scale-Revised (FSDS-R) total score at week 24 | 7.0 | -4.0 |
| Percent with clinically meaningful improvement in FSDS-R total score at week 24 | 34% | 50% |
Table: Efficacy Results of Vyleesi Clinical Trials
Dosage and administration of Vyleesi
As a self-administered injection for women struggling with low libido, Vyleesi is available in two forms: a single-dose, pre-filled autoinjector and a multi-dose, reusable pen device. Before using Vyleesi, it is best to consult with a healthcare provider to determine the correct dosage for the individual patient’s needs.
- Vyleesi should be administered subcutaneously in the abdomen or thigh at least 45 minutes before anticipated sexual activity.
- The recommended starting dose of Vyleesi is 0.75 mg, with a maximum of one dose within 24 hours and a maximum of eight doses per month.
- If a patient does not experience an improvement in sexual desire or experiences adverse effects, it is essential to discuss dosage changes with a healthcare provider.
While Vyleesi can be self-administered, it is crucial to follow proper injection techniques and dispose of used materials properly to avoid the risk of infection and needle injury.
To monitor patient response and safety, healthcare providers may require follow-up visits to assess adequate dosage and measure side effects of Vyleesi treatment.
| Dosage & Administration of Vyleesi | Instructions |
|---|---|
| Storage | Refrigerate Vyleesi at 2°C to 8°C (36°F to 46°F) |
| Preparation | Allow pre-filled autoinjector or multi-dose pen to reach room temperature before use. Swirl solution in the syringe before use. |
| Injection | Administer subcutaneously at least 45 minutes before sexual activity. Do not inject into veins or muscles. |
| Dosage | 0.75 mg, with a maximum of one dose within 24 hours and a maximum of eight doses per month. |
| Follow-up | Follow-up visits with healthcare provider may be required to assess adequate dosage and measure side effects of Vyleesi treatment. |
With proper dosage and administration of Vyleesi treatment, women experiencing low libido may see a positive improvement in their sexual desire and satisfaction.
Effectiveness of Vyleesi
As a treatment for hypoactive sexual desire disorder (HSDD) in premenopausal women, Vyleesi has been marketed as a promising option to address the lack of sex drive. Here’s what you need to know about its effectiveness:
- Studies have shown that Vyleesi increases the likelihood of sexual desire and satisfying sexual events for women with HSDD, compared to those who took a placebo (a non-active substance).
- However, the percentage of women who experienced significant improvement was relatively small. In one clinical trial, only about 25% of women who received Vyleesi reported an increase in their sexual desire, compared to roughly 17% of those who took the placebo.
- The effectiveness of Vyleesi may also depend on individual factors such as age, relationship status, and other health concerns that may impact women’s sex lives.
While Vyleesi may offer benefits for some women struggling with HSDD, it’s important to consider the limitations and possible side effects of the drug. As with any medication, it’s recommended to discuss the risks and benefits of Vyleesi with a healthcare provider and explore other potential treatment options as well.
That being said, if you are considering Vyleesi as a treatment option for HSDD, it’s worth noting that the drug is designed to be taken as-needed, meaning that you only have to take it when you want to have sex. Additionally, the effects of the medication can last for up to 12 hours after taking it, which can give plenty of time to enjoy intimate moments with a partner.
| Effectiveness of Vyleesi: | Percentage of Women Reporting Significant Improvement |
|---|---|
| Compared to placebo: | 25% |
| General population: | Not determined |
Overall, Vyleesi may offer some benefits for women with HSDD, but it’s important to understand the limitations and individual factors that may impact its effectiveness. If you’re considering Vyleesi as a treatment option, speak with your healthcare provider to learn more about its benefits, side effects, and potential risks.
Side effects of Vyleesi
If you are considering using Vyleesi for treating your hypoactive sexual desire disorder (HSDD), you should be aware of potential side effects that may occur. While Vyleesi is generally well-tolerated, some people may experience adverse reactions. Below are some common side effects of Vyleesi:
- Nausea
- Flushing
- Headache
- Injection site reactions, like pain or itching
- Hot flashes
- Fainting or loss of consciousness (syncope)
If you experience any of these side effects, you should talk to your doctor immediately. In rare cases, Vyleesi can also cause more severe complications like blood pressure changes.
According to the Vyleesi prescribing information, most side effects occur within the first 30 minutes after injection and last for an hour. They tend to be mild to moderate in severity and resolve on their own. However, if you have persistent or severe symptoms, you may need medical attention.
| Side effect | Incidence |
|---|---|
| Nausea | 19% |
| Flushing | 16% |
| Headache | 10% |
| Injection site reaction | 9% |
| Hot flashes | 7% |
| Syncope | 1% |
The table above shows the incidence of common side effects observed during clinical trials of Vyleesi. You can use this information as a reference to understand the likelihood of experiencing certain side effects. However, keep in mind that individual response to medications may vary, and not everyone will experience the same side effects.
In conclusion, Vyleesi is a safe and effective treatment for HSDD, but like any medication, it can cause side effects. It is important to be aware of potential adverse reactions and to communicate any concerns with your healthcare provider. Your doctor can help you decide if Vyleesi is right for you and provide you with guidance on how to manage any side effects.
Interactions with other medications
It is important to consult with a healthcare provider prior to taking Vyleesi, as it can interact with other medications. Some of the medications that may interact with Vyleesi include:
- Antidepressants
- Blood pressure medications
- Drugs for erectile dysfunction
- Sedatives
Additionally, Vyleesi can increase the risk of low blood pressure if taken with certain medications, such as alpha-blockers or nitrates.
It is also important to note that Vyleesi may interact with herbal supplements or over-the-counter medications. Therefore, it is essential to disclose all medications and supplements taken to the healthcare provider before starting Vyleesi.
Vyleesi and Alcohol
Consuming alcohol while taking Vyleesi may increase the risk of low blood pressure and fainting. Therefore, it is advisable to avoid alcohol while taking Vyleesi.
Vyleesi and Pregnancy
Vyleesi is not recommended for use during pregnancy. The safety and effectiveness of Vyleesi in pregnant women have not been established.
Vyleesi and Breastfeeding
The safety of Vyleesi during breastfeeding is unknown, and it is not recommended for use during breastfeeding.
Vyleesi Dosage and Timing with Other Medications
| Medication | Vyleesi Dosage and Timing |
| Oral Contraceptives | The administration of Vyleesi should be timed to avoid the peak hormonal levels of oral contraceptives. For example, Vyleesi can be administered on days when the lowest amount of hormones are present in the bloodstream. |
| Levothyroxine | Vyleesi may decrease the effectiveness of levothyroxine. Therefore, it is recommended to take levothyroxine at least four hours before or after the administration of Vyleesi. |
It is essential to follow the healthcare provider’s instructions on Vyleesi dosage and timing when taking other medications to avoid any potential interactions.
Contraindications for Vyleesi
Vyleesi is a prescription medication designed to treat hypoactive sexual desire disorder (HSDD) in premenopausal women. However, there are certain circumstances when Vyleesi should not be taken. These contraindications include:
- Known hypersensitivity to the active ingredient or any of the components of Vyleesi
- Uncontrolled hypertension or cardiovascular disease
- History of cerebral vascular accident or transient ischemic attack
- History of unstable angina or myocardial infarction
- History of severe hepatic impairment
- Use of strong CYP3A4 inhibitors
- Pregnancy or trying to conceive
- Breastfeeding
If you have any of these contraindications, it is important to speak with your healthcare provider before taking Vyleesi. In addition, it is important to inform your healthcare provider of any other medical conditions you have, as well as any medications or supplements you may be taking, before starting Vyleesi.
Overall, while Vyleesi can be an effective treatment for HSDD in premenopausal women, it is important to carefully consider its use under the guidance of a healthcare provider.
More Information on Vyleesi
If you are interested in learning more about Vyleesi, including how long it lasts and what the potential side effects may be, speak with your healthcare provider or pharmacist. They can provide you with more detailed information and help you determine if Vyleesi is right for you.
| Drug Interactions | Effect on Vyleesi |
|---|---|
| Strong CYP3A4 inhibitors | Increased Vyleesi levels |
| Strong CYP3A4 inducers | Decreased Vyleesi levels |
| Erythromycin | Increased Vyleesi levels |
| Ketoconazole | Increased Vyleesi levels |
It is important to note that this table is not a comprehensive list of all potential drug interactions with Vyleesi. Always consult with your healthcare provider before taking any new medications or supplements, including Vyleesi.
Cost of Vyleesi
Vyleesi, a medication used to treat hypoactive sexual desire disorder (HSDD) in women, is available in the market with a prescription and is usually self-injected into the thigh or abdomen at least 45 minutes before sexual activity. With its potential effectiveness in treating HSDD, one of the primary concerns of patients and healthcare professionals alike is the cost of the medication.
- The price of Vyleesi may vary depending on the pharmacy and location.
- On average, a single dose of Vyleesi may cost around $400, making it not accessible for everyone.
- Patients who are insured may have a lower out-of-pocket cost, while those who are not may have difficulty affording it.
It is essential to note that the cost of Vyleesi may not be the only expense that patients will incur. Other factors to consider include the cost of doctor consultations and check-ups, as well as other treatments or medications that may address the root of the HSDD issue.
Before starting any medication, it is always crucial to discuss with a healthcare professional the potential benefits and risks of the treatment, as well as the costs that come with it. Patients can also explore options such as patient assistance programs to help mitigate the cost of the medication.
| Price comparison of Vyleesi in different pharmacies | Pharmacy location | Price per dose |
|---|---|---|
| CVS | New York, NY | $398.00 |
| Walgreens | Los Angeles, CA | $409.89 |
| Rite Aid | Houston, TX | $393.21 |
In conclusion, while Vyleesi may be a promising treatment option for women with HSDD, the cost of the medication should also be considered as it may affect accessibility for some patients. It is encouraged that patients discuss with their healthcare provider to explore all available treatment options, as well as the potential benefits and risks of Vyleesi before making any decisions.
Alternatives to Vyleesi
If Vyleesi is not the right treatment option for you, there are other alternatives available:
- Oral medications: There are several FDA-approved medications for treating hypoactive sexual desire disorder (HSDD), including Addyi (flibanserin) and Tefina (testosterone). These medications are taken orally and work by targeting the chemicals in the brain that affect sexual desire.
- Hormonal therapy: Hormone replacement therapy (HRT) may be an effective option for women experiencing reduced libido due to menopause or other hormonal imbalances. HRT involves taking hormones to restore balance to the body and alleviate symptoms of menopause.
- Psychological counseling: If your reduced libido is due to psychological factors such as stress, anxiety, or relationship issues, counseling may be an effective treatment option. A therapist can help you work through these issues and develop strategies for improving your sex life.
It’s important to discuss all of your treatment options with your healthcare provider to determine the best course of action for you.
Comparison of Vyleesi and Other Treatments
Here’s a comparison table of Vyleesi and other commonly used treatments for HSDD:
| Treatment | Method of Administration | Efficacy | Potential Side Effects | Cost |
|---|---|---|---|---|
| Vyleesi | Subcutaneous injection | Increases satisfying sexual events by 1-2 per month | Nausea, flushing, headache | Approximately $900 per injection |
| Addyi | Oral tablet | Increases satisfying sexual events by 0.5-1 per month | Dizziness, fatigue, nausea, dry mouth | Approximately $500 per month |
| Tefina | Nasal spray | Improves sexual arousal and desire | Headache, nausea, nasal irritation | Not currently available for purchase |
| Psychological counseling | N/A | Improves sexual desire and function | N/A | Approximately $100-$250 per session |
Keep in mind that the efficacy, side effects, and cost of each treatment can vary depending on the individual. It’s important to work closely with your healthcare provider to determine the best treatment plan for your specific needs.
FAQs on How Long Does Vyleesi Last
Q: How long does a single dose of Vyleesi last?
A: Typically, one dose of Vyleesi can last for up to 24 hours.
Q: How often can I take Vyleesi?
A: You should take Vyleesi at least 45 minutes before sexual activity, and no more than once in a 24-hour period.
Q: How long does it take for Vyleesi to work?
A: Vyleesi usually takes effect within 45 minutes of taking it.
Q: Can Vyleesi be used for men?
A: No, Vyleesi is only approved for use in premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD).
Q: How long should I use Vyleesi?
A: Vyleesi should only be used as needed, and you should consult with your healthcare provider to determine whether it is right for you.
Q: Is Vyleesi safe?
A: Vyleesi is generally considered safe, but it may cause side effects such as nausea, flushing, and headache. Always follow your healthcare provider’s instructions when taking Vyleesi.
Q: Can I drink alcohol while taking Vyleesi?
A: It is not recommended to consume alcohol while taking Vyleesi, as it may increase the risk of side effects.
Closing: Thanks for Choosing Us!
We hope that this article has provided you with valuable information on how long Vyleesi lasts and how to use it safely. Remember, it is important to always follow your healthcare provider’s instructions and ask any questions you may have. Thank you for choosing us, and we hope to see you again soon!